E-ISSN 1658-8088 | ISSN 1658-807X
 

Original Article

Online Publishing Date:
07 / 01 / 2020

 


Attitudes of geneticists and patients toward incidental findings in Saudi Arabia

Taghrid Aloraini, Alya Abdulrahim, Gulsan A. Karbani.


Abstract
Background: In Middle East countries, including Saudi Arabia, 60%–70% of all marriages occur between first cousins, leading to uniquely common genetic disorders compared to Western countries. The primary objective of this study is to investigate differences between the attitudes of genetics professionals and patients toward incidental findings identified through whole-genome sequencing (WGS)/whole exome sequencing (WES). Methodology: A mixed qualitative and quantitative cross-sectional study was done to assess the ethical dilemmas and challenges faced in providing genetic information to Saudi patients attending a genetics clinic. A webbased survey was used to interview the participants. A total of 50 subjects were enrolled in this cross-sectional study, including 20 genetics professionals (MG: medical geneticists and GC: genetic counselors) and 30 patients who were interviewed before and after Next-Generation Sequencing tests. Results: Among the total, 55% of genetic professionals disagreed on patients being provided with their genetic results and raw data, and they preferred focusing on actionable results that yield benefits such as medical treatment and disease prevention. However, the majority of patients (73.3%) were interested in receiving all the raw genomic data for themselves and their children, while 26.7% felt opposite. Conclusion: This study identified differences in the attitudes of genetics professionals and patients toward the reporting of incidental findings from WES/WGS. Overall, the results suggested that GCand MGshould be aware of variations in individual preferences and should respect the beliefs and preferences of their patients.

Key words: WES, WGS, incidental findings, attitudes, genetics professionals, patients.


 
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How to Cite this Article
Pubmed Style

Aloraini T, Abdulrahim A, Karbani GA. Attitudes of geneticists and patients toward incidental findings in Saudi Arabia. JBCGenetics. 2019; 2(2): 116-121. doi:10.24911/JBCGenetics/183-1563863536


Web Style

Aloraini T, Abdulrahim A, Karbani GA. Attitudes of geneticists and patients toward incidental findings in Saudi Arabia. https://www.jbcgenetics.com/?mno=58142 [Access: March 14, 2024]. doi:10.24911/JBCGenetics/183-1563863536


AMA (American Medical Association) Style

Aloraini T, Abdulrahim A, Karbani GA. Attitudes of geneticists and patients toward incidental findings in Saudi Arabia. JBCGenetics. 2019; 2(2): 116-121. doi:10.24911/JBCGenetics/183-1563863536



Vancouver/ICMJE Style

Aloraini T, Abdulrahim A, Karbani GA. Attitudes of geneticists and patients toward incidental findings in Saudi Arabia. JBCGenetics. (2019), [cited March 14, 2024]; 2(2): 116-121. doi:10.24911/JBCGenetics/183-1563863536



Harvard Style

Aloraini, T., Abdulrahim, . A. & Karbani, . G. A. (2019) Attitudes of geneticists and patients toward incidental findings in Saudi Arabia. JBCGenetics, 2 (2), 116-121. doi:10.24911/JBCGenetics/183-1563863536



Turabian Style

Aloraini, Taghrid, Alya Abdulrahim, and Gulsan A. Karbani. 2019. Attitudes of geneticists and patients toward incidental findings in Saudi Arabia. Journal of Biochemical and Clinical Genetics, 2 (2), 116-121. doi:10.24911/JBCGenetics/183-1563863536



Chicago Style

Aloraini, Taghrid, Alya Abdulrahim, and Gulsan A. Karbani. "Attitudes of geneticists and patients toward incidental findings in Saudi Arabia." Journal of Biochemical and Clinical Genetics 2 (2019), 116-121. doi:10.24911/JBCGenetics/183-1563863536



MLA (The Modern Language Association) Style

Aloraini, Taghrid, Alya Abdulrahim, and Gulsan A. Karbani. "Attitudes of geneticists and patients toward incidental findings in Saudi Arabia." Journal of Biochemical and Clinical Genetics 2.2 (2019), 116-121. Print. doi:10.24911/JBCGenetics/183-1563863536



APA (American Psychological Association) Style

Aloraini, T., Abdulrahim, . A. & Karbani, . G. A. (2019) Attitudes of geneticists and patients toward incidental findings in Saudi Arabia. Journal of Biochemical and Clinical Genetics, 2 (2), 116-121. doi:10.24911/JBCGenetics/183-1563863536





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