Short Communication
Published: Nov 02, 2025 | DOI: 10.24911/ejmcr.9-2356
IVF Empowered by NGS: Redefining Reproductive Medicine Through PGT-A and PGT-M
Authors: Qamre Alam , Mohamed Ali Ateyah , Mohamed Hani Ali , Kadhem Alkhenaizi
Article Info
Authors
Qamre Alam
Molecular Genomics and Precision Medicine Department, EXPRESSMED Diagnostics and Research, Zinj, Bahrain
Mohamed Ali Ateyah
Molecular Genomics and Precision Medicine Department, EXPRESSMED Diagnostics and Research, Zinj, Bahrain
Mohamed Hani Ali
Molecular Genomics and Precision Medicine Department, EXPRESSMED Diagnostics and Research, Zinj, Bahrain
Kadhem Alkhenaizi
Molecular Genomics and Precision Medicine Department, EXPRESSMED Diagnostics and Research, Zinj, Bahrain
Publication History
Received: September 04, 2025
Accepted: October 08, 2025
Published: November 02, 2025
Abstract
Genetic disorders remain among the greatest challenges in modern medicine, with over 95% lacking curative therapies. Preimplantation Genetic Testing (PGT) has emerged as a transformative preventive tool, enabling the detection of chromosomal abnormalities (PGT-A) and single-gene disorders (PGT-M) in embryos prior to implantation. At ExpressMed Diagnostics and Research, Bahrain, nearly 700 PGT-A and 25 PGT-M cases have been performed, with a significant impact on reducing miscarriage risk and preventing sickle cell disease transmission. Our data highlight the critical influence of maternal age, with aneuploidy rates rising from ~60% in women under 30 to ~90% in women over 40. In the Gulf region, where consanguinity and genetic disorders are highly prevalent, PGT offers a powerful public health strategy to reduce inherited disease burden, complementing newborn screening and premarital testing. As genomic technologies advance, ensuring accessibility, affordability, and ethical oversight will be essential. PGT represents not only a scientific breakthrough but also a shift in reproductive medicine from treatment to prevention, with profound implications for future generations.
Keywords: PGT-A, PGT-M, Reproductive Gentics, NGS, Precision Medicine
Pubmed Style
Qamre Alam, Mohamed Ali Ateyah, Mohamed Hani Ali, Kadhem Alkhenaizi. IVF Empowered by NGS: Redefining Reproductive Medicine Through PGT-A and PGT-M. JBC Genetics. 2025; 02 (November 2025): -. doi:10.24911/ejmcr.9-2356
Web Style
Qamre Alam, Mohamed Ali Ateyah, Mohamed Hani Ali, Kadhem Alkhenaizi. IVF Empowered by NGS: Redefining Reproductive Medicine Through PGT-A and PGT-M. https://jbcgenetics.com/index.php/articles/2356 [Access: November 03, 2025]. doi:10.24911/ejmcr.9-2356
AMA (American Medical Association) Style
Qamre Alam, Mohamed Ali Ateyah, Mohamed Hani Ali, Kadhem Alkhenaizi. IVF Empowered by NGS: Redefining Reproductive Medicine Through PGT-A and PGT-M. JBC Genetics. 2025; 02 (November 2025): -. doi:10.24911/ejmcr.9-2356
Vancouver/ICMJE Style
Qamre Alam, Mohamed Ali Ateyah, Mohamed Hani Ali, Kadhem Alkhenaizi. IVF Empowered by NGS: Redefining Reproductive Medicine Through PGT-A and PGT-M. JBC Genetics. (2025), [cited November 03, 2025]; 02 (November 2025): -. doi:10.24911/ejmcr.9-2356
Harvard Style
Qamre Alam, Mohamed Ali Ateyah, Mohamed Hani Ali, Kadhem Alkhenaizi (2025) IVF Empowered by NGS: Redefining Reproductive Medicine Through PGT-A and PGT-M. JBC Genetics, 02 (November 2025): -. doi:10.24911/ejmcr.9-2356
Chicago Style
Qamre Alam, Mohamed Ali Ateyah, Mohamed Hani Ali, Kadhem Alkhenaizi. " IVF Empowered by NGS: Redefining Reproductive Medicine Through PGT-A and PGT-M." 02 (2025), -. doi:10.24911/ejmcr.9-2356
MLA (The Modern Language Association) Style
Qamre Alam, Mohamed Ali Ateyah, Mohamed Hani Ali, Kadhem Alkhenaizi. " IVF Empowered by NGS: Redefining Reproductive Medicine Through PGT-A and PGT-M." 02.November 2025 (2025), -. Print. doi:10.24911/ejmcr.9-2356
APA (American Psychological Association) Style
Qamre Alam, Mohamed Ali Ateyah, Mohamed Hani Ali, Kadhem Alkhenaizi (2025) IVF Empowered by NGS: Redefining Reproductive Medicine Through PGT-A and PGT-M. , 02 (November 2025), -. doi:10.24911/ejmcr.9-2356