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Case Report 


Dilated cardiomyopathy associated with NRAP gene: a case series

Abdellh A. Names, Mohammed A. Tohary, Basel A. Hadad, Abdurahman H. Alhazmi, Hamad M. Alaksham, Hassan M. Gohal, Ghadah M. Gosadi, Ali A. Awaji, Mohammad A. Jareebi.

Abstract
Background: The genetic basis of dilated cardiomyopathy (DCM) is highly diverse, with over 100 known genes and several possibilities described. Nebulin-related-anchoring protein (NRAP) is an action-binding cytoskeletal protein that has a role in the myofibrillar assembly in the embryonic heart. It is primarily generated in striated and cardiac muscles.
Case Presentation: We described three cases of DCM that were related to NRAP gene mutations [NM_001261463.1: c.3568G > T; p. (Glu1190*)].
Conclusion: Our data imply that biallelic nonsense mutations in the NRAP might be a genetic risk factor with limited penetrance and induce DCM at various ages.

Key words: NRAP gene, heart failure, cardiomyopathies, DCM, genetics.


 
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How to Cite this Article
Pubmed Style

Names AA, Tohary MA, Hadad BA, Alhazmi AH, Alaksham HM, Gohal HM, Gosadi GM, Awaji AA, Jareebi MA. Dilated cardiomyopathy associated with NRAP gene: a case series. JBCGenetics. 2023; 6(1): 70-74. doi:10.24911/JBCGenetics/183-1668575222

Web Style

Names AA, Tohary MA, Hadad BA, Alhazmi AH, Alaksham HM, Gohal HM, Gosadi GM, Awaji AA, Jareebi MA. Dilated cardiomyopathy associated with NRAP gene: a case series. https://www.jbcgenetics.com//?mno=130301 [Access: August 15, 2023]. doi:10.24911/JBCGenetics/183-1668575222

AMA (American Medical Association) Style

Names AA, Tohary MA, Hadad BA, Alhazmi AH, Alaksham HM, Gohal HM, Gosadi GM, Awaji AA, Jareebi MA. Dilated cardiomyopathy associated with NRAP gene: a case series. JBCGenetics. 2023; 6(1): 70-74. doi:10.24911/JBCGenetics/183-1668575222


Vancouver/ICMJE Style

Names AA, Tohary MA, Hadad BA, Alhazmi AH, Alaksham HM, Gohal HM, Gosadi GM, Awaji AA, Jareebi MA. Dilated cardiomyopathy associated with NRAP gene: a case series. JBCGenetics. (2023), [cited August 15, 2023]; 6(1): 70-74. doi:10.24911/JBCGenetics/183-1668575222


Harvard Style

Names, A. A., Tohary, . M. A., Hadad, . B. A., Alhazmi, . A. H., Alaksham, . H. M., Gohal, . H. M., Gosadi, . G. M., Awaji, . A. A. & Jareebi, . M. A. (2023) Dilated cardiomyopathy associated with NRAP gene: a case series. JBCGenetics, 6 (1), 70-74. doi:10.24911/JBCGenetics/183-1668575222


Turabian Style

Names, Abdellh A., Mohammed A. Tohary, Basel A. Hadad, Abdurahman H. Alhazmi, Hamad M. Alaksham, Hassan M. Gohal, Ghadah M. Gosadi, Ali A. Awaji, and Mohammad A. Jareebi. 2023. Dilated cardiomyopathy associated with NRAP gene: a case series. Journal of Biochemical and Clinical Genetics, 6 (1), 70-74. doi:10.24911/JBCGenetics/183-1668575222


Chicago Style

Names, Abdellh A., Mohammed A. Tohary, Basel A. Hadad, Abdurahman H. Alhazmi, Hamad M. Alaksham, Hassan M. Gohal, Ghadah M. Gosadi, Ali A. Awaji, and Mohammad A. Jareebi. "Dilated cardiomyopathy associated with NRAP gene: a case series." Journal of Biochemical and Clinical Genetics 6 (2023), 70-74. doi:10.24911/JBCGenetics/183-1668575222


MLA (The Modern Language Association) Style

Names, Abdellh A., Mohammed A. Tohary, Basel A. Hadad, Abdurahman H. Alhazmi, Hamad M. Alaksham, Hassan M. Gohal, Ghadah M. Gosadi, Ali A. Awaji, and Mohammad A. Jareebi. "Dilated cardiomyopathy associated with NRAP gene: a case series." Journal of Biochemical and Clinical Genetics 6.1 (2023), 70-74. Print. doi:10.24911/JBCGenetics/183-1668575222


APA (American Psychological Association) Style

Names, A. A., Tohary, . M. A., Hadad, . B. A., Alhazmi, . A. H., Alaksham, . H. M., Gohal, . H. M., Gosadi, . G. M., Awaji, . A. A. & Jareebi, . M. A. (2023) Dilated cardiomyopathy associated with NRAP gene: a case series. Journal of Biochemical and Clinical Genetics, 6 (1), 70-74. doi:10.24911/JBCGenetics/183-1668575222




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