Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma

Qing Yue; Wei Han; Ziling Liu; Zain Abbas; Akmal Zubair; Saba Beigh; Hayaa Mohammad Alhuthali; Hind A. Alzahrani; Rasha Mohammed Saleem; Nahed S. Alharthi

doi:10.24911/JBCGenetics/183-1674209873

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Original Article

Online Publishing Date:
04 / 02 / 2024

JBCGenetics. 2023; 6(2): 097-105

doi: 10.24911/JBCGenetics/183-1674209873

Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma

Qing Yue, Wei Han, Ziling Liu, Zain Abbas, Akmal Zubair, Saba Beigh, Hayaa Mohammad Alhuthali, Hind A. Alzahrani, Rasha Mohammed Saleem, Nahed S. Alharthi.

Abstract
Abstract
Purpose: The purpose of this paper is to construct and validate the immune-related prognostic signature in lung squamous cell carcinoma through integrated bioinformatics analysis. Methods: We constructed an optimized prognostic risk model consisting of five PIR-lncRNAs (AC107884.1, LCMT1-AS1, AL163051.1, AC005730.3 and LINC02635). We then performed survival analysis and independent prognostic analysis on the prognostic risk model to assess and validate the prognostic value of the model. Further, we performed differential analysis of immune cell infiltration between high- and low-risk patients in the model. Results: In this article, we obtained 546 differentially expressed genes and 21 immune-related genes, identified 654 immune-related lncRNAs (IR-lncRNAs) by co-expression network analysis, and identified 18 prognostic IR-lncRNAs (PIR-lncRNAs) by univariate Cox analysis. Through the analysis of immune escape and immunotherapy, we verified that the effect of immunotherapy in high-risk group patients may be lower. Conclusion: Our findings elucidate the intrinsic molecular biological link between the pathogenic genes of lung squamous cell carcinoma (LUSC) and immune cells, which has important exploration and reference significance for the precise and potential immunotherapy of LUSC patients, especially for high-risk patients.

Key words: immune-related genes; lncRNAs; lung squamous cell carcinoma; prognostic risk model; immune cell infiltration; immunotherapy.

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How to Cite this Article

Pubmed Style

Yue Q, Han W, Liu Z, Abbas Z, Zubair A, Beigh S, Alhuthali HM, Alzahrani HA, Saleem RM, Alharthi NS. Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma. JBCGenetics. 2023; 6(2): 097-105. doi:10.24911/JBCGenetics/183-1674209873

Web Style

Yue Q, Han W, Liu Z, Abbas Z, Zubair A, Beigh S, Alhuthali HM, Alzahrani HA, Saleem RM, Alharthi NS. Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma. https://www.jbcgenetics.com/?mno=141357 [Access: March 14, 2024]. doi:10.24911/JBCGenetics/183-1674209873

AMA (American Medical Association) Style

Yue Q, Han W, Liu Z, Abbas Z, Zubair A, Beigh S, Alhuthali HM, Alzahrani HA, Saleem RM, Alharthi NS. Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma. JBCGenetics. 2023; 6(2): 097-105. doi:10.24911/JBCGenetics/183-1674209873

Vancouver/ICMJE Style

Yue Q, Han W, Liu Z, Abbas Z, Zubair A, Beigh S, Alhuthali HM, Alzahrani HA, Saleem RM, Alharthi NS. Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma. JBCGenetics. (2023), [cited March 14, 2024]; 6(2): 097-105. doi:10.24911/JBCGenetics/183-1674209873

Harvard Style

Yue, Q., Han, . W., Liu, . Z., Abbas, . Z., Zubair, . A., Beigh, . S., Alhuthali, . H. M., Alzahrani, . H. A., Saleem, . R. M. & Alharthi, . N. S. (2023) Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma. JBCGenetics, 6 (2), 097-105. doi:10.24911/JBCGenetics/183-1674209873

Turabian Style

Yue, Qing, Wei Han, Ziling Liu, Zain Abbas, Akmal Zubair, Saba Beigh, Hayaa Mohammad Alhuthali, Hind A. Alzahrani, Rasha Mohammed Saleem, and Nahed S. Alharthi. 2023. Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma. Journal of Biochemical and Clinical Genetics, 6 (2), 097-105. doi:10.24911/JBCGenetics/183-1674209873

Chicago Style

Yue, Qing, Wei Han, Ziling Liu, Zain Abbas, Akmal Zubair, Saba Beigh, Hayaa Mohammad Alhuthali, Hind A. Alzahrani, Rasha Mohammed Saleem, and Nahed S. Alharthi. "Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma." Journal of Biochemical and Clinical Genetics 6 (2023), 097-105. doi:10.24911/JBCGenetics/183-1674209873

MLA (The Modern Language Association) Style

Yue, Qing, Wei Han, Ziling Liu, Zain Abbas, Akmal Zubair, Saba Beigh, Hayaa Mohammad Alhuthali, Hind A. Alzahrani, Rasha Mohammed Saleem, and Nahed S. Alharthi. "Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma." Journal of Biochemical and Clinical Genetics 6.2 (2023), 097-105. Print. doi:10.24911/JBCGenetics/183-1674209873

APA (American Psychological Association) Style

Yue, Q., Han, . W., Liu, . Z., Abbas, . Z., Zubair, . A., Beigh, . S., Alhuthali, . H. M., Alzahrani, . H. A., Saleem, . R. M. & Alharthi, . N. S. (2023) Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma. Journal of Biochemical and Clinical Genetics, 6 (2), 097-105. doi:10.24911/JBCGenetics/183-1674209873

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