JBCGenetics |

Original Article

Volume: 8 | Issue: 1 | Published: Jun 24, 2025 | Pages: 020 - 026 | DOI: 10.24911/JBCGenetics.11-2222

CFTR interactome may impact gastric cancer: an in silico system-level coexpression analysis

Authors: Camila Sinimbú Forte , Amanda Ferreira Vidal , Pablo Diego do Carmo Pinto , Gilderlanio Santana de Araújo

Article Info

Authors

Camila Sinimbú Forte

Institute of Technology, Federal University of Pará, Belém, Brazil

Amanda Ferreira Vidal

Vale Institute of Technology, Belém, Brazil

Pablo Diego do Carmo Pinto

Institute of Medical Sciences, Federal University of Pará, Belém, Brazil

Gilderlanio Santana de Araújo

Institute of Biological Sciences, Federal University of Pará, Belém, Brazil

ORCID

Publication History

Received: May 18, 2025

Accepted: June 16, 2025

Published: June 24, 2025

Abstract

Background: The cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction is linked to gastrointestinal inflammation and has been implicated in early-onset malignancies. However, its role in gastric cancer remains poorly understood.

Aims: To investigate the CFTR interactome and assess its potential functional involvement across different subtypes of gastric cancer.

Methods: We conducted a system-level in silico analysis using data from the Cancer Genome Atlas Stomach Adenocarcinoma (TCGA-STAD). CFTR expression and co-expression profiles were examined across molecular and histological subtypes of gastric cancer, including signet-ring cell carcinoma (Lauren’s classification). Differential gene expression (DGE) and co-expression analyses were integrated with protein-protein interaction networks, pathway enrichment, and gene ontology (GO) analysis to delineate CFTR’s functional associations.

Results: CFTR did not exhibit significant differential expression across gastric cancer subtypes. However, co-expression analysis identified CFTR as a key hub gene with a distinct interaction network, especially prominent in the signet-ring cell carcinoma subtype. Enrichment analyses revealed that CFTR's interactome is involved in regulatory pathways related to cellular homeostasis, ion transport, and immune modulation, suggesting a noncanonical yet critical role in tumor biology.

Conclusion: While CFTR expression remains stable across gastric cancer subtypes, its interactome reveals significant regulatory roles, particularly in signet-ring cell carcinoma. These findings highlight the potential contribution of CFTR to gastric cancer pathogenesis through its involvement in broader molecular networks rather than through expression changes alone.

Keywords: Gene co-expression network, CFTR, gastric cancer subtypes, signet-ring cell carcinoma

Pubmed Style

Camila Sinimbú Forte, Amanda Ferreira Vidal, Pablo Diego do Carmo Pinto, Gilderlanio Santana de Araújo. CFTR interactome may impact gastric cancer: an in silico system-level coexpression analysis. JBC Genetics. 2025; 24 (June 2025): 020-026. doi:10.24911/JBCGenetics.11-2222

Web Style

Camila Sinimbú Forte, Amanda Ferreira Vidal, Pablo Diego do Carmo Pinto, Gilderlanio Santana de Araújo. CFTR interactome may impact gastric cancer: an in silico system-level coexpression analysis. https://jbcgenetics.com/articles/2222 [Access: August 08, 2025]. doi:10.24911/JBCGenetics.11-2222

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Camila Sinimbú Forte, Amanda Ferreira Vidal, Pablo Diego do Carmo Pinto, Gilderlanio Santana de Araújo. CFTR interactome may impact gastric cancer: an in silico system-level coexpression analysis. JBC Genetics. (2025), [cited August 08, 2025]; 24 (June 2025): 020-026. doi:10.24911/JBCGenetics.11-2222

Harvard Style

Camila Sinimbú Forte, Amanda Ferreira Vidal, Pablo Diego do Carmo Pinto, Gilderlanio Santana de Araújo (2025) CFTR interactome may impact gastric cancer: an in silico system-level coexpression analysis. JBC Genetics, 24 (June 2025): 020-026. doi:10.24911/JBCGenetics.11-2222

Chicago Style

Camila Sinimbú Forte, Amanda Ferreira Vidal, Pablo Diego do Carmo Pinto, Gilderlanio Santana de Araújo. "CFTR interactome may impact gastric cancer: an in silico system-level coexpression analysis." 24 (2025), 020-026. doi:10.24911/JBCGenetics.11-2222

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Camila Sinimbú Forte, Amanda Ferreira Vidal, Pablo Diego do Carmo Pinto, Gilderlanio Santana de Araújo (2025) CFTR interactome may impact gastric cancer: an in silico system-level coexpression analysis. , 24 (June 2025), 020-026. doi:10.24911/JBCGenetics.11-2222