E-ISSN 1658-8088 | ISSN 1658-807X
 
2023, Vol: 6, Issue: 2
6 / 2Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles
Required files to be uploaded

Title Page

Original Article

Online Publishing Date:
16 / 12 / 2022

 


Genetic impact of non-consanguineous marriages in Saudi Arabia.

Mohammed Alyahya, Taghrid Aloraini, Youseef Al-Harbi, Lamia Alsubaie, Abdulrahman Alswaid, Wafaa Eyaid, Fuad Al Mutairi, Faroug Ababneh, Majid Alfadhel, Ahmed Alfares.


Abstract
Background: Physicians and geneticists face challenges in making accurate diagnoses during clinical evaluations; affecting patients and clinicians. The aim of this study was to estimate the hit rate of the non-consanguineous population. Moreover, prevalence of the genetic disorder in both the consanguineous and non- consanguineous population of Saudi Arabia at King Abdulaziz Medical City in Riyadh data.
Methods: We reviewed 681 families and 1563 individuals with 2,565,335 variants in the King Abdullah International Medical Research Center (KAIMRC) Genomic Database (KGD), Riyadh, Saudi Arabia. All the ES requests were obtained from the physician and clinical geneticist of KAIMRC, and the test was performed either in-house or in a College of American Pathologists accredited laboratory center for clinical purposes.
Results: A total of 151 non-consanguineous individuals with exome sequencing requests in the population genomic database of King Abdullah International Medical Research Center was considered for the study. In total, 27 had disease-causing variants, and the hit rate was 27/151 (18%). Among the 28 different variants in the 27 individuals, 50% were de novo variants and 50% inherited. The hit rate of the variants causing autosomal recessive disorders was 12/28 (42.8%), autosomal dominant disorders 13/28 (46.4%), and X-linked disorders 3/28 (10.7%).
Conclusion: Non-consanguineous marriages have a lower risk of genetic disorders, and reducing consanguinity reduces the risk of genetic disorders by two to three times.
 

Key words: Saudi Arabia, non-consanguineous, ES, hit rate.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Mohammed Alyahya
Articles by Taghrid Aloraini
Articles by Youseef Al-Harbi
Articles by Lamia Alsubaie
Articles by Abdulrahman Alswaid
Articles by Wafaa Eyaid
Articles by Fuad Al Mutairi
Articles by Faroug Ababneh
Articles by Majid Alfadhel
Articles by Ahmed Alfares
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Alyahya M, Aloraini T, Al-Harbi Y, Alsubaie L, Alswaid A, Eyaid W, Mutairi FA, Ababneh F, Alfadhel M, Alfares A. Genetic impact of non-consanguineous marriages in Saudi Arabia.. JBCGenetics. 2022; 5(2): 37-42. doi:10.24911/JBCGenetics/183-1664872492

Web Style

Alyahya M, Aloraini T, Al-Harbi Y, Alsubaie L, Alswaid A, Eyaid W, Mutairi FA, Ababneh F, Alfadhel M, Alfares A. Genetic impact of non-consanguineous marriages in Saudi Arabia.. https://www.jbcgenetics.com/?mno=119085 [Access: March 13, 2024]. doi:10.24911/JBCGenetics/183-1664872492

AMA (American Medical Association) Style

Alyahya M, Aloraini T, Al-Harbi Y, Alsubaie L, Alswaid A, Eyaid W, Mutairi FA, Ababneh F, Alfadhel M, Alfares A. Genetic impact of non-consanguineous marriages in Saudi Arabia.. JBCGenetics. 2022; 5(2): 37-42. doi:10.24911/JBCGenetics/183-1664872492


Vancouver/ICMJE Style

Alyahya M, Aloraini T, Al-Harbi Y, Alsubaie L, Alswaid A, Eyaid W, Mutairi FA, Ababneh F, Alfadhel M, Alfares A. Genetic impact of non-consanguineous marriages in Saudi Arabia.. JBCGenetics. (2022), [cited March 13, 2024]; 5(2): 37-42. doi:10.24911/JBCGenetics/183-1664872492


Harvard Style

Alyahya, M., Aloraini, . T., Al-Harbi, . Y., Alsubaie, . L., Alswaid, . A., Eyaid, . W., Mutairi, . F. A., Ababneh, . F., Alfadhel, . M. & Alfares, . A. (2022) Genetic impact of non-consanguineous marriages in Saudi Arabia.. JBCGenetics, 5 (2), 37-42. doi:10.24911/JBCGenetics/183-1664872492


Turabian Style

Alyahya, Mohammed, Taghrid Aloraini, Youseef Al-Harbi, Lamia Alsubaie, Abdulrahman Alswaid, Wafaa Eyaid, Fuad Al Mutairi, Faroug Ababneh, Majid Alfadhel, and Ahmed Alfares. 2022. Genetic impact of non-consanguineous marriages in Saudi Arabia.. Journal of Biochemical and Clinical Genetics, 5 (2), 37-42. doi:10.24911/JBCGenetics/183-1664872492


Chicago Style

Alyahya, Mohammed, Taghrid Aloraini, Youseef Al-Harbi, Lamia Alsubaie, Abdulrahman Alswaid, Wafaa Eyaid, Fuad Al Mutairi, Faroug Ababneh, Majid Alfadhel, and Ahmed Alfares. "Genetic impact of non-consanguineous marriages in Saudi Arabia.." Journal of Biochemical and Clinical Genetics 5 (2022), 37-42. doi:10.24911/JBCGenetics/183-1664872492


MLA (The Modern Language Association) Style

Alyahya, Mohammed, Taghrid Aloraini, Youseef Al-Harbi, Lamia Alsubaie, Abdulrahman Alswaid, Wafaa Eyaid, Fuad Al Mutairi, Faroug Ababneh, Majid Alfadhel, and Ahmed Alfares. "Genetic impact of non-consanguineous marriages in Saudi Arabia.." Journal of Biochemical and Clinical Genetics 5.2 (2022), 37-42. Print. doi:10.24911/JBCGenetics/183-1664872492


APA (American Psychological Association) Style

Alyahya, M., Aloraini, . T., Al-Harbi, . Y., Alsubaie, . L., Alswaid, . A., Eyaid, . W., Mutairi, . F. A., Ababneh, . F., Alfadhel, . M. & Alfares, . A. (2022) Genetic impact of non-consanguineous marriages in Saudi Arabia.. Journal of Biochemical and Clinical Genetics, 5 (2), 37-42. doi:10.24911/JBCGenetics/183-1664872492




Most Viewed Articles
Most Accessed Articles

  • Frontonasal dysplasia: a review
    Muhammad Umair, Farooq Ahmad, Muhammad Bilal, Muhammad Arshad
    JBCGenetics. 2018; 1(2): 66-76
    » Abstract » doi: 10.24911/JBCGenetics/183-1530765389

  • The role of C-terminal tensin-like (Cten) gene in cancer metastasis
    Saleh Alghamdi, Sarah Alkwai, Mohammad Ilyas
    JBCGenetics. 2018; 1(1): 2-9
    » Abstract » doi: 10.24911/JBCGenetics/183-1531548689

  • Clinical reassessment of post-laboratory variant call format (VCF) files
    Lamia Alsubaie, Saeed Alturki, Ali Alothaim, Ahmed Alfares
    JBCGenetics. 2018; 1(1): 31-36
    » Abstract » doi: 10.24911/JBCGenetics/183-1529928114

  • Microcephalic osteodysplastic primordial dwarfism type II and Klinefelter syndrome: report of two competing growth syndromes
    AlAnoud Al-Jarbou, Afnan Al-Turki, Suha Tashkandi, Eissa A. Faqeih
    JBCGenetics. 2018; 1(1): 37-39
    » Abstract » doi: 10.24911/JBCGenetics/183-1530040885

  • Recessive ARFGEF2 mutation causes progressive microcephaly, epilepsy, and a distinct MRI pattern
    Maram Alojair, Abdulaziz Alghamdi, Kalthoum Tlili, Sateesh Maddirevula, Fowzan Sami Alkuraya, Brahim Tabarki
    JBCGenetics. 2018; 1(1): 40-42
    » Abstract » doi: 10.24911/JBCGenetics/183-1531469195

    •
    Most Downloaded
    Top Downloaded Articles

  • Frontonasal dysplasia: a review
    Muhammad Umair, Farooq Ahmad, Muhammad Bilal, Muhammad Arshad
    JBCGenetics. 2018; 1(2): 66-76
    » Abstract » doi: 10.24911/JBCGenetics/183-1530765389

  • Generation of a mouse model of Primary Hyperoxaluria Type 1 via CRISPR/Cas9 mediated gene editing
    Kimberly A Coughlan, Rajanikanth J Maganti, Andrea Frassetto, Christine M DeAntonis, meredith Wolfrom, Anne-Renee Graham, Shawn M Hillier, Steven Fortucci, Hoor Al Jandal, Sue-Jean Hong, Paloma H Giangrande, Paolo GV Martini,
    JBCGenetics. 2019; 2(1): 28-39
    » Abstract » doi: 10.24911/JBCGenetics/183-1542047633

  • Syndactyly genes and classification: a mini review
    Muhammad Umair, Farooq Ahmad, Muhammad Bilal, Safdar Abbas
    JBCGenetics. 2018; 1(1): 10-18
    » Abstract » doi: 10.24911/JBCGenetics/183-1532177257

  • Recessive ARFGEF2 mutation causes progressive microcephaly, epilepsy, and a distinct MRI pattern
    Maram Alojair, Abdulaziz Alghamdi, Kalthoum Tlili, Sateesh Maddirevula, Fowzan Sami Alkuraya, Brahim Tabarki
    JBCGenetics. 2018; 1(1): 40-42
    » Abstract » doi: 10.24911/JBCGenetics/183-1531469195

  • Consanguinity, awareness, and genetic disorders among female university students in Riyadh, Saudi Arabia
    Hadil Alahdal, Huda Alshanbari, Hana Saud Almazroa, Sarah Majed Alayesh, Alaa Mohammad Alrhaili, Nora Alqubi, Fai Fahad Alzamil, Reem Albassam
    JBCGenetics. 2021; 4(1): 27-34
    » Abstract » doi: 10.24911/JBCGenetics/183-1601264923

    •
    Most Cited Articles
    Most Cited Articles

  • Frontonasal dysplasia: a review
    Muhammad Umair, Farooq Ahmad, Muhammad Bilal, Muhammad Arshad
    JBCGenetics. 2018; 1(2): 66-76
    » Abstract » doi: 10.24911/JBCGenetics/183-1530765389
    Cited : 4 times [Click to see citing articles]

  • Syndactyly genes and classification: a mini review
    Muhammad Umair, Farooq Ahmad, Muhammad Bilal, Safdar Abbas
    JBCGenetics. 2018; 1(1): 10-18
    » Abstract » doi: 10.24911/JBCGenetics/183-1532177257
    Cited : 4 times [Click to see citing articles]

  • Genomics in Saudi Arabia Call for Data-Sharing Policy
    Ahmed Alfares,
    JBCGenetics. 2018; 1(2): 51-52
    » Abstract » doi: 10.24911/JBCGenetics/183-1546945268
    Cited : 4 times [Click to see citing articles]

  • Consanguinity, awareness, and genetic disorders among female university students in Riyadh, Saudi Arabia
    Hadil Alahdal, Huda Alshanbari, Hana Saud Almazroa, Sarah Majed Alayesh, Alaa Mohammad Alrhaili, Nora Alqubi, Fai Fahad Alzamil, Reem Albassam
    JBCGenetics. 2021; 4(1): 27-34
    » Abstract » doi: 10.24911/JBCGenetics/183-1601264923
    Cited : 2 times [Click to see citing articles]

  • Harel-Yoon syndrome: the first case report from Saudi Arabia
    Alaa AlAyed, Manar A. Samman, Abdul Ali Peer-Zada, Mohammed Almannai
    JBCGenetics. 2020; 3(1): 22-27
    » Abstract » doi: 10.24911/JBCGenetics/183-1585816398
    Cited : 2 times [Click to see citing articles]

    •

    About Journal of Biochemical and Clinical Genetics

    The Journal of Biochemical and Clinical Genetics (JBCGenetics) is a peer-reviewed, open access medical journal. Owner:  Saudi Society of Medical ... Read more.



    For best results, please use Internet Explorer or Google Chrome.

    Contact Information

    Title Owner: Saudi Society of Medical Genetics

    https://ssmg.org.sa/en

    Society Email: info@ssmg.org.sa

    Editor in Chief: dralfadhelm@jbcgenetics.com

    Contact the publisher:

    contact@discoverpublish.com
    https://discoverpublish.com/ 

    Publisher: Discover STM Publishing Ltd, 

    82 Leslie's Arch, Old Quarter, Ballincollig, Cork, P31 RY62, Ireland.

    Hours:  M-F: 8:30am - 5:30pm

    Contact Emails:

    Journal Editorial Office:  contact@jbcgenetics.com

    Billing Support:  contact@discoverpublish.com

    Technical Support:
    anastasiia.pavlenco@sofiafields.com
    https://sofiafields.com/ 
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    About Publisher
    Advertising Policy
    Author's Rights and Obligations
    Conflict of Interest Policy
    Copyright Information
    Digital Archiving & Preservation Policies
    Editorial Policies
    Peer Review Policy
    Editorial & Peer Review Process
    License Information
    Open Access Policy
    Plagiarism Policy
    Privacy Policy
    Protection of Research Participants (Statement On Human And Animal Rights)
    Publication Ethics and Publication Malpractice Statement
    Corrections, Retractions & Expressions of Concern
    Self-Archiving Policies
    Statement of Informed Consent
    Terms of Use