E-ISSN 1658-8088 | ISSN 1658-807X
 

Review Article 


Syndactyly genes and classification: a mini review

Muhammad Umair, Farooq Ahmad, Muhammad Bilal, Safdar Abbas.

Cited By: 3

Abstract
Syndactyly (Syn = together; Dactylos = digits) is the most common limb defect mostly characterized by webbing of digits. It may be webbing with or without bony fusion and inherited mostly in autosomal dominant manner, although also reported as autosomal recessive, X-linked or isolated entity. It also shows diverse clinical and phenotypic heterogeneity and mostly observed as unilateral or bilateral and symmetrical or asymmetrical forms. Syndactyly mostly occurs either as an isolated anomaly or as a part of a complex syndrome (+150 syndromes). Here, non-syndromic syndactyly has been classified according to genetic and molecular basis. The non-syndromic syndactyly has been classified into nine different types. Up till now, the major genes identified to cause hereditary syndactyly are mainly involved in the sonic hedgehog pathway and zone of polarizing activity. The present review mostly focuses on summarizing the recent advances in molecular genetics, including known genes and loci responsible for non-syndromic syndactyly. The present review will contribute to the understanding of the pathogenesis underlying non-syndromic and syndromic syndactyly, improving clinical and molecular diagnosis; thus, making genetic counseling and prenatal testing easier in future.
Keywords: Limb malformation, syndactyly, digit webbing, molecular genetics.

Key words: Limb Malformation, Syndactyly, Digit webbing, Molecular genetics


 
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How to Cite this Article
Pubmed Style

Umair M, Ahmad F, Bilal M, Abbas S. Syndactyly genes and classification: a mini review. JBCGenetics. 2018; 1(1): 10-18. doi:10.24911/JBCGenetics/183-1532177257


Web Style

Umair M, Ahmad F, Bilal M, Abbas S. Syndactyly genes and classification: a mini review. https://www.jbcgenetics.com/?mno=2066 [Access: December 05, 2023]. doi:10.24911/JBCGenetics/183-1532177257


AMA (American Medical Association) Style

Umair M, Ahmad F, Bilal M, Abbas S. Syndactyly genes and classification: a mini review. JBCGenetics. 2018; 1(1): 10-18. doi:10.24911/JBCGenetics/183-1532177257



Vancouver/ICMJE Style

Umair M, Ahmad F, Bilal M, Abbas S. Syndactyly genes and classification: a mini review. JBCGenetics. (2018), [cited December 05, 2023]; 1(1): 10-18. doi:10.24911/JBCGenetics/183-1532177257



Harvard Style

Umair, M., Ahmad, . F., Bilal, . M. & Abbas, . S. (2018) Syndactyly genes and classification: a mini review. JBCGenetics, 1 (1), 10-18. doi:10.24911/JBCGenetics/183-1532177257



Turabian Style

Umair, Muhammad, Farooq Ahmad, Muhammad Bilal, and Safdar Abbas. 2018. Syndactyly genes and classification: a mini review. Journal of Biochemical and Clinical Genetics, 1 (1), 10-18. doi:10.24911/JBCGenetics/183-1532177257



Chicago Style

Umair, Muhammad, Farooq Ahmad, Muhammad Bilal, and Safdar Abbas. "Syndactyly genes and classification: a mini review." Journal of Biochemical and Clinical Genetics 1 (2018), 10-18. doi:10.24911/JBCGenetics/183-1532177257



MLA (The Modern Language Association) Style

Umair, Muhammad, Farooq Ahmad, Muhammad Bilal, and Safdar Abbas. "Syndactyly genes and classification: a mini review." Journal of Biochemical and Clinical Genetics 1.1 (2018), 10-18. Print. doi:10.24911/JBCGenetics/183-1532177257



APA (American Psychological Association) Style

Umair, M., Ahmad, . F., Bilal, . M. & Abbas, . S. (2018) Syndactyly genes and classification: a mini review. Journal of Biochemical and Clinical Genetics, 1 (1), 10-18. doi:10.24911/JBCGenetics/183-1532177257





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