Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population

Muhsin Elmas; Mustafa Solak; Mehmet Yaman; Saliha Handan Yildiz; Mujgan Erdogan; Tulay Koken

doi:10.24911/JBCGenetics/183-1582098144

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Original Article
Online Published: 14 May 2020

JBCGenetics. 2020; 3(1): 3-6

doi: 10.24911/JBCGenetics/183-1582098144

Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population

Muhsin Elmas, Mustafa Solak, Mehmet Yaman, Saliha Handan Yildiz, Mujgan Erdogan, Tulay Koken.

Abstract
Background: Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. In this study, we investigated the possible association of vitamin D levels and rs703842 in the CYP27B1 gene with MS.
Methodology: We used blood samples of 99 patients (65 female, 35 male) with an magnetic resonance imaging (MRI)-confirmed definitive diagnosis of MS and 99 controls (70 female, 29 male) between the ages of 18-55 years. We measured their vitamin D levels, isolated their DNA, and scanned rs703842 polymorphism in the CYP27B1 gene.
Results: Rs703842 polymorphism in the CYP27B1 gene in humans was found as three different genotypes: CC, CT, and TT. Among them, CC genotype was found higher in the patient group and CT genotype was found higher in the control group. The statistical analysis showed that the probability of a C allele having an association with MS to be 1.5189 times of the probability of T allele. Also, the vitamin D levels in the patient group were detected lower than the control group.
Conclusion: Low levels of vitamin D and low expression of CYP27B1 were found to have an association with MS.

Key words: Multiple sclerosis, vitamin D, 25-Hydroxyvitamin D3 1-alpha-Hydroxylase

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How to Cite this Article

Pubmed Style

Elmas M, Solak M, Yaman M, Yildiz SH, Erdogan M, Koken T. Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population. JBCGenetics. 2020; 3(1): 3-6. doi:10.24911/JBCGenetics/183-1582098144

Web Style

Elmas M, Solak M, Yaman M, Yildiz SH, Erdogan M, Koken T. Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population. https://www.jbcgenetics.com/?mno=87872 [Access: November 14, 2024]. doi:10.24911/JBCGenetics/183-1582098144

AMA (American Medical Association) Style

Elmas M, Solak M, Yaman M, Yildiz SH, Erdogan M, Koken T. Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population. JBCGenetics. 2020; 3(1): 3-6. doi:10.24911/JBCGenetics/183-1582098144

Vancouver/ICMJE Style

Elmas M, Solak M, Yaman M, Yildiz SH, Erdogan M, Koken T. Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population. JBCGenetics. (2020), [cited November 14, 2024]; 3(1): 3-6. doi:10.24911/JBCGenetics/183-1582098144

Harvard Style

Elmas, M., Solak, . M., Yaman, . M., Yildiz, . S. H., Erdogan, . M. & Koken, . T. (2020) Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population. JBCGenetics, 3 (1), 3-6. doi:10.24911/JBCGenetics/183-1582098144

Turabian Style

Elmas, Muhsin, Mustafa Solak, Mehmet Yaman, Saliha Handan Yildiz, Mujgan Erdogan, and Tulay Koken. 2020. Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population. Journal of Biochemical and Clinical Genetics, 3 (1), 3-6. doi:10.24911/JBCGenetics/183-1582098144

Chicago Style

Elmas, Muhsin, Mustafa Solak, Mehmet Yaman, Saliha Handan Yildiz, Mujgan Erdogan, and Tulay Koken. "Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population." Journal of Biochemical and Clinical Genetics 3 (2020), 3-6. doi:10.24911/JBCGenetics/183-1582098144

MLA (The Modern Language Association) Style

Elmas, Muhsin, Mustafa Solak, Mehmet Yaman, Saliha Handan Yildiz, Mujgan Erdogan, and Tulay Koken. "Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population." Journal of Biochemical and Clinical Genetics 3.1 (2020), 3-6. Print. doi:10.24911/JBCGenetics/183-1582098144

APA (American Psychological Association) Style

Elmas, M., Solak, . M., Yaman, . M., Yildiz, . S. H., Erdogan, . M. & Koken, . T. (2020) Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population. Journal of Biochemical and Clinical Genetics, 3 (1), 3-6. doi:10.24911/JBCGenetics/183-1582098144

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