Review Article
Volume: 1 | Issue: 2 | Published: Nov 30, 2018 | Pages: 57 - 65 | DOI: 10.24911/JBCGenetics/183-1540811228
Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review
Authors:
Khalid Siddiqui
, Mohthash Musambil
, Adnan Mahmood Usmani
Article Info
Authors
Khalid Siddiqui
Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi Arabia
Mohthash Musambil
Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi Arabia
Adnan Mahmood Usmani
Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi Arabia
Publication History
Received: March 05, 2018
Accepted: May 18, 2018
Published: November 30, 2018
Abstract
Type 2 Diabetes (T2D) is a polygenic and multi-factorial complex disease. The significant challenge of finding genetic markers that could be used to predict T2D risk remains unresolved. Saudi Arabia is one of several ethnicities with a high prevalence rate of T2D. A large number of studies have been performed that explored genetic factors associated with T2D risk. In this work, we conducted a systematic review of published studies on T2D genetic markers in the Saudi population. Multiple databases were employed in the literature review, which focused on studies that either reported the association or non-association of a genetic marker with T2D risk. Using appropriate search terms, we collected, analyzed, and selected 428 articles published between the years of 2000-2018, Of these, 18 articles reported a total of 67 polymorphisms in 46 genes that are strongly linked to T2D in the Saudi population. Most of the relevant studies used genotyping as the primary methodology to identify genetic markers of T2D. Most of these studies were published between the years of 2012-2017. A total of 23 polymorphisms in 17 genes were found to be associated with T2D risk in the Saudi population: KCNJ11, PPARG2, IRS1, VDE, WFS1, JAZF1, CDKN2A/B, TCF7L2, KCNQ1, HNF4A, DUSP9, APOE, HNF1A, SLC30A8, APOC3, SNAP25, and ACE.
Keywords: Type 2 diabetes, Genetics, Saudi Arabia
Pubmed Style
Khalid Siddiqui, Mohthash Musambil, Adnan Mahmood Usmani. Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. JBC Genetics. 2018; 30 (November 2018): 57-65. doi:10.24911/JBCGenetics/183-1540811228
Web Style
Khalid Siddiqui, Mohthash Musambil, Adnan Mahmood Usmani. Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. https://jbcgenetics.com/articles/2113 [Access: June 02, 2025]. doi:10.24911/JBCGenetics/183-1540811228
AMA (American Medical Association) Style
Khalid Siddiqui, Mohthash Musambil, Adnan Mahmood Usmani. Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. JBC Genetics. 2018; 30 (November 2018): 57-65. doi:10.24911/JBCGenetics/183-1540811228
Vancouver/ICMJE Style
Khalid Siddiqui, Mohthash Musambil, Adnan Mahmood Usmani. Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. JBC Genetics. (2018), [cited June 02, 2025]; 30 (November 2018): 57-65. doi:10.24911/JBCGenetics/183-1540811228
Harvard Style
Khalid Siddiqui, Mohthash Musambil, Adnan Mahmood Usmani (2018) Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. JBC Genetics, 30 (November 2018): 57-65. doi:10.24911/JBCGenetics/183-1540811228
Chicago Style
Khalid Siddiqui, Mohthash Musambil, Adnan Mahmood Usmani. "Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review." 30 (2018), 57-65. doi:10.24911/JBCGenetics/183-1540811228
MLA (The Modern Language Association) Style
Khalid Siddiqui, Mohthash Musambil, Adnan Mahmood Usmani. "Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review." 30.November 2018 (2018), 57-65. Print. doi:10.24911/JBCGenetics/183-1540811228
APA (American Psychological Association) Style
Khalid Siddiqui, Mohthash Musambil, Adnan Mahmood Usmani (2018) Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. , 30 (November 2018), 57-65. doi:10.24911/JBCGenetics/183-1540811228