Review Article
JBCGenetics. 2020; 3(2): 94-99

Prevention of hemoglobinopathies in Saudi Arabia: efficacy of national premarital screening and the feasibility of preimplantation genetic diagnosis

Authors: Muhammad Umair, Majid Alfadhel.

View PDF HTML Fulltext DOI: 10.24911/JBCGenetics/183-1595487640

Abstract

Hemoglobinopathies constitute the most frequent, inherited single-gene disorders. Its prevalence is increasing substantially and might cause a substantial economic burden on affected families and countries. The current study findings recommend population screening strategies to be implemented for severe disorders such as sickle-cell disease, hemoglobin E disease, α- and β-thalassemia, and normal individuals to identify the carrier status and manage the disease pathogenesis. In addition, national registries should highlight the information and contribute to the proper management and care of patients suffering from hemoglobinopathy. Furthermore, the Saudi Government should provide a conceptual framework to determine the specific preventive strategies to manage the incidence of hemoglobinopathies effectively.

Keywords:   Hemoglobinopathies, sickle cell, α-thalassemia, newborn population screening, β-thalassemia


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Prevention of hemoglobinopathies in Saudi Arabia: efficacy of national premarital screening and the feasibility of preimplantation genetic diagnosis


Authors
Muhammad Umair
Medical Genomics Research Department, King Abdullah International Medical Research Center (KAIMRC), King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia
PubMed articlesGoogle scholar articles

Majid Alfadhel
Medical Genomics Research Department, King Abdullah International Medical Research Center (KAIMRC), King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia
PubMed articlesGoogle scholar articles


Correspondence to:
. Majid Alfadhel, Genetics Division, Department of Pediatrics, King Abdullah Specialized Childrens Hospital, King Abdulaziz Medical City, Riyadh, Saudi Arabia.; dralfadhelm@gmail.com

Publication history
Received 23 Jul 2020
Revised 19 Aug 2020
Accepted 06 Sep 2020
Published online 19 Sep 2020
Published in print 30 Sep 2020

How to cite this article

Pubmed Style

Umair M, Alfadhel M. Prevention of hemoglobinopathies in Saudi Arabia: efficacy of national premarital screening and the feasibility of preimplantation genetic diagnosis. JBCGenetics. 2020; 3(2): 94-99. doi:10.24911/JBCGenetics/183-1595487640


Web Style

Umair M, Alfadhel M. Prevention of hemoglobinopathies in Saudi Arabia: efficacy of national premarital screening and the feasibility of preimplantation genetic diagnosis. https://www.jbcgenetics.com//?mno=108572 [Access: January 19, 2021]. doi:10.24911/JBCGenetics/183-1595487640


AMA (American Medical Association) Style

Umair M, Alfadhel M. Prevention of hemoglobinopathies in Saudi Arabia: efficacy of national premarital screening and the feasibility of preimplantation genetic diagnosis. JBCGenetics. 2020; 3(2): 94-99. doi:10.24911/JBCGenetics/183-1595487640


Vancouver/ICMJE Style

Umair M, Alfadhel M. Prevention of hemoglobinopathies in Saudi Arabia: efficacy of national premarital screening and the feasibility of preimplantation genetic diagnosis. JBCGenetics. (2020), [cited January 19, 2021]; 3(2): 94-99. doi:10.24911/JBCGenetics/183-1595487640


Harvard Style

Umair, M. & Alfadhel, . M. (2020) Prevention of hemoglobinopathies in Saudi Arabia: efficacy of national premarital screening and the feasibility of preimplantation genetic diagnosis. JBCGenetics, 3 (2), 94-99. doi:10.24911/JBCGenetics/183-1595487640


Turabian Style

Umair, Muhammad, and Majid Alfadhel. 2020. Prevention of hemoglobinopathies in Saudi Arabia: efficacy of national premarital screening and the feasibility of preimplantation genetic diagnosis. Journal of Biochemical and Clinical Genetics, 3 (2), 94-99. doi:10.24911/JBCGenetics/183-1595487640


Chicago Style

Umair, Muhammad, and Majid Alfadhel. "Prevention of hemoglobinopathies in Saudi Arabia: efficacy of national premarital screening and the feasibility of preimplantation genetic diagnosis." Journal of Biochemical and Clinical Genetics 3 (2020), 94-99. doi:10.24911/JBCGenetics/183-1595487640


MLA (The Modern Language Association) Style

Umair, Muhammad, and Majid Alfadhel. "Prevention of hemoglobinopathies in Saudi Arabia: efficacy of national premarital screening and the feasibility of preimplantation genetic diagnosis." Journal of Biochemical and Clinical Genetics 3.2 (2020), 94-99. Print. doi:10.24911/JBCGenetics/183-1595487640


APA (American Psychological Association) Style

Umair, M. & Alfadhel, . M. (2020) Prevention of hemoglobinopathies in Saudi Arabia: efficacy of national premarital screening and the feasibility of preimplantation genetic diagnosis. Journal of Biochemical and Clinical Genetics, 3 (2), 94-99. doi:10.24911/JBCGenetics/183-1595487640


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