Review Article
JBCGenetics. 2018; 1(1): 19-25

Molecular genetics of inherited kidney disease in Saudi Arabia

Authors: Mohamed H Al-Hamed, Faiqa Imtiaz, Jameela Kari.

View PDF HTML Fulltext DOI: 10.24911/JBCGenetics/183-1529935373

Abstract

Human kidneys serve important physiological functions in the body. There is an increasing evidence suggesting that the majority of renal diseases have an underlying genetic component. At least 40 genes have been shown to be involved in kidney development and many more genes are expressed within the kidney and regulate renal physiology. It is observed that genetic and congenital disorders are more common in Arab countries than in industrialized countries. Saudi Arabia is the largest Arab country and estimation of patients with end-stage kidney failure is 136 for each million yearly. Preliminary observations indicate that children in Saudi Arabia probably have a higher incidence of polycystic kidney disease, familial juvenile nephronophthisis, congenital urological anomalies, and familial nephrotic syndrome. Molecular diagnosis would help enormously in prevention and introduce early management which could ensure a better outcome. This is a review article of molecular studies conducted in the Kingdom of Saudi Arabia from 1990 till present time to elucidate disease-causing genes of inherited kidney disease.

Keywords:   Inherited kidney disease, mutations, molecular genetics, consanguinity, Saudi Arabia


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Molecular genetics of inherited kidney disease in Saudi Arabia


Authors
Mohamed H Al-Hamed
Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabi
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Faiqa Imtiaz
Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Jameela Kari
Pediatric Nephrology Center of Excellence and Pediatric Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
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Correspondence to:
Mohamed H Al-Hamed. Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia; hamed@kfshrc.edu.sa

Publication history
Received 23 Nov 2017
Revised 13 Dec 2017
Accepted 19 Dec 2017
Published in print 01 Jan 2018

How to cite this article

Pubmed Style

Al-Hamed MH, Imtiaz F, Kari J. Molecular genetics of inherited kidney disease in Saudi Arabia. JBCGenetics. 2018; 1(1): 19-25. doi:10.24911/JBCGenetics/183-1529935373


Web Style

Al-Hamed MH, Imtiaz F, Kari J. Molecular genetics of inherited kidney disease in Saudi Arabia. https://www.jbcgenetics.com//?mno=302730 [Access: December 13, 2018]. doi:10.24911/JBCGenetics/183-1529935373


AMA (American Medical Association) Style

Al-Hamed MH, Imtiaz F, Kari J. Molecular genetics of inherited kidney disease in Saudi Arabia. JBCGenetics. 2018; 1(1): 19-25. doi:10.24911/JBCGenetics/183-1529935373


Vancouver/ICMJE Style

Al-Hamed MH, Imtiaz F, Kari J. Molecular genetics of inherited kidney disease in Saudi Arabia. JBCGenetics. (2018), [cited December 13, 2018]; 1(1): 19-25. doi:10.24911/JBCGenetics/183-1529935373


Harvard Style

Al-Hamed, M. H., Imtiaz, . F. & Kari, . J. (2018) Molecular genetics of inherited kidney disease in Saudi Arabia. JBCGenetics, 1 (1), 19-25. doi:10.24911/JBCGenetics/183-1529935373


Turabian Style

Al-Hamed, Mohamed H, Faiqa Imtiaz, and Jameela Kari. 2018. Molecular genetics of inherited kidney disease in Saudi Arabia. Journal of Biochemical and Clinical Genetics, 1 (1), 19-25. doi:10.24911/JBCGenetics/183-1529935373


Chicago Style

Al-Hamed, Mohamed H, Faiqa Imtiaz, and Jameela Kari. "Molecular genetics of inherited kidney disease in Saudi Arabia." Journal of Biochemical and Clinical Genetics 1 (2018), 19-25. doi:10.24911/JBCGenetics/183-1529935373


MLA (The Modern Language Association) Style

Al-Hamed, Mohamed H, Faiqa Imtiaz, and Jameela Kari. "Molecular genetics of inherited kidney disease in Saudi Arabia." Journal of Biochemical and Clinical Genetics 1.1 (2018), 19-25. Print. doi:10.24911/JBCGenetics/183-1529935373


APA (American Psychological Association) Style

Al-Hamed, M. H., Imtiaz, . F. & Kari, . J. (2018) Molecular genetics of inherited kidney disease in Saudi Arabia. Journal of Biochemical and Clinical Genetics, 1 (1), 19-25. doi:10.24911/JBCGenetics/183-1529935373


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