Original Article
JBCGenetics. 2020; 3(1): 3-6

Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population

Authors: Muhsin Elmas, Mustafa Solak, Mehmet Yaman, Saliha Handan Yildiz, Mujgan Erdogan, Tulay Koken.

View PDF HTML Fulltext DOI: 10.24911/JBCGenetics/183-1582098144

Abstract

Background: Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. In this study, we investigated the possible association of vitamin D levels and rs703842 in the CYP27B1 gene with MS. Methodology: We used blood samples of 99 patients (65 female, 35 male) with an magnetic resonance imaging (MRI)-confirmed definitive diagnosis of MS and 99 controls (70 female, 29 male) between the ages of 18-55 years. We measured their vitamin D levels, isolated their DNA, and scanned rs703842 polymorphism in the CYP27B1 gene. Results: Rs703842 polymorphism in the CYP27B1 gene in humans was found as three different genotypes: CC, CT, and TT. Among them, CC genotype was found higher in the patient group and CT genotype was found higher in the control group. The statistical analysis showed that the probability of a C allele having an association with MS to be 1.5189 times of the probability of T allele. Also, the vitamin D levels in the patient group were detected lower than the control group. Conclusion: Low levels of vitamin D and low expression of CYP27B1 were found to have an association with MS.

Keywords:   Multiple sclerosis, vitamin D, 25-Hydroxyvitamin D3 1-alpha-Hydroxylase


Request permissions

If you wish to reuse any part or all of this article please contact the copyright holder, contact@jbcgenetics.com.

Copyright ©2020. All Rights Reserved.

Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population


Authors
Muhsin Elmas
Department of Medical Genetics, Afyonkarahisar Health Sciences University, Western Anatolia, Turkey
PubMed articlesGoogle scholar articles

Mustafa Solak
Department of Medical Genetics, Afyonkarahisar Health Sciences University, Western Anatolia, Turkey
PubMed articlesGoogle scholar articles

Mehmet Yaman
Department of Neurology, Afyon Kocatepe University, Western Anatolia, Turkey
PubMed articlesGoogle scholar articles

Saliha Handan Yildiz
Department of Medical Genetics, Afyonkarahisar Health Sciences University, Western Anatolia, Turkey
PubMed articlesGoogle scholar articles

Mujgan Erdogan
Department of Medical Genetics, Afyonkarahisar Health Sciences University, Western Anatolia, Turkey
PubMed articlesGoogle scholar articles

Tulay Koken
Department of Medical Genetics, Afyonkarahisar Health Sciences University, Western Anatolia, Turkey
PubMed articlesGoogle scholar articles


Correspondence to:
. Muhsin Elmas, Department of Medical Genetics, Afyonkarahisar Health Sciences University, Western Anatolia, Turkey; drmelmas@gmail.com

Publication history
Received 19 Feb 2020
Revised 12 Mar 2020
Accepted 07 Apr 2020
Published online 14 May 2020
Published in print 27 May 2020

How to cite this article

Pubmed Style

Elmas M, Solak M, Yaman M, Yildiz SH, Erdogan M, Koken T. Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population. JBCGenetics. 2020; 3(1): 3-6. doi:10.24911/JBCGenetics/183-1582098144


Web Style

Elmas M, Solak M, Yaman M, Yildiz SH, Erdogan M, Koken T. Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population. https://www.jbcgenetics.com//?mno=87872 [Access: October 27, 2020]. doi:10.24911/JBCGenetics/183-1582098144


AMA (American Medical Association) Style

Elmas M, Solak M, Yaman M, Yildiz SH, Erdogan M, Koken T. Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population. JBCGenetics. 2020; 3(1): 3-6. doi:10.24911/JBCGenetics/183-1582098144


Vancouver/ICMJE Style

Elmas M, Solak M, Yaman M, Yildiz SH, Erdogan M, Koken T. Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population. JBCGenetics. (2020), [cited October 27, 2020]; 3(1): 3-6. doi:10.24911/JBCGenetics/183-1582098144


Harvard Style

Elmas, M., Solak, . M., Yaman, . M., Yildiz, . S. H., Erdogan, . M. & Koken, . T. (2020) Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population. JBCGenetics, 3 (1), 3-6. doi:10.24911/JBCGenetics/183-1582098144


Turabian Style

Elmas, Muhsin, Mustafa Solak, Mehmet Yaman, Saliha Handan Yildiz, Mujgan Erdogan, and Tulay Koken. 2020. Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population. Journal of Biochemical and Clinical Genetics, 3 (1), 3-6. doi:10.24911/JBCGenetics/183-1582098144


Chicago Style

Elmas, Muhsin, Mustafa Solak, Mehmet Yaman, Saliha Handan Yildiz, Mujgan Erdogan, and Tulay Koken. "Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population." Journal of Biochemical and Clinical Genetics 3 (2020), 3-6. doi:10.24911/JBCGenetics/183-1582098144


MLA (The Modern Language Association) Style

Elmas, Muhsin, Mustafa Solak, Mehmet Yaman, Saliha Handan Yildiz, Mujgan Erdogan, and Tulay Koken. "Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population." Journal of Biochemical and Clinical Genetics 3.1 (2020), 3-6. Print. doi:10.24911/JBCGenetics/183-1582098144


APA (American Psychological Association) Style

Elmas, M., Solak, . M., Yaman, . M., Yildiz, . S. H., Erdogan, . M. & Koken, . T. (2020) Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population. Journal of Biochemical and Clinical Genetics, 3 (1), 3-6. doi:10.24911/JBCGenetics/183-1582098144


Click the icon of the social media platform on which you would like to share this article.