Review Article
JBCGenetics. 2018; 1(1): 2-9

The role of C-terminal tensin-like (Cten) gene in cancer metastasis

Authors: Saleh Alghamdi, Sarah Alkwai, Mohammad Ilyas.

View PDF HTML Fulltext DOI: 10.24911/JBCGenetics/183-1531548689

Abstract

C-terminal tensin-like (cten, also known as tensin4, TNS4) is the fourth member of the tensin family. all tensin family members localizes in focal adhesion sites. Cten shares the sequence homology with other tensins at its C-terminal region by having the SH2 and PTB domains. Cten is expressed in some normal tissue such as prostate and placenta while down-regulated in prostate cancer. The overexpression of cten was found associates with tumors of breast, colon, lung, stomach, skin and pancreas. It interacts with growth factors and cytokines as regulators. Also it has been found that cten expression promotes cell motility and enhances tumorigenicity. The collective findings support that cten is having a role in carcinogenesis and promising biomarker. It can be a candidate for a therapeutic target for solid cancers.

Keywords:   Cten, colorectal cancer, tensin, metastasis


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The role of C-terminal tensin-like (Cten) gene in cancer metastasis


Authors
Saleh Alghamdi
King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Medical Genomics Research Department, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia
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Sarah Alkwai
King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Medical Genomics Research Department, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia
PubMed articlesGoogle scholar articles

Mohammad Ilyas
Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham Molecular Pathology Node, United Kingdom
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Correspondence to:
. Saleh Alghamdi, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Medical Genomics Research Department, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; alghamdisa7@ngha.med.sa

Publication history
Received 15 Oct 2017
Revised 15 Nov 2017
Accepted 03 Dec 2017
Published in print 01 Jan 2018

How to cite this article

Pubmed Style

Alghamdi S, Alkwai S, Ilyas M. The role of C-terminal tensin-like (Cten) gene in cancer metastasis. JBCGenetics. 2018; 1(1): 2-9. doi:10.24911/JBCGenetics/183-1531548689


Web Style

Alghamdi S, Alkwai S, Ilyas M. The role of C-terminal tensin-like (Cten) gene in cancer metastasis. https://www.jbcgenetics.com//?mno=978 [Access: December 13, 2018]. doi:10.24911/JBCGenetics/183-1531548689


AMA (American Medical Association) Style

Alghamdi S, Alkwai S, Ilyas M. The role of C-terminal tensin-like (Cten) gene in cancer metastasis. JBCGenetics. 2018; 1(1): 2-9. doi:10.24911/JBCGenetics/183-1531548689


Vancouver/ICMJE Style

Alghamdi S, Alkwai S, Ilyas M. The role of C-terminal tensin-like (Cten) gene in cancer metastasis. JBCGenetics. (2018), [cited December 13, 2018]; 1(1): 2-9. doi:10.24911/JBCGenetics/183-1531548689


Harvard Style

Alghamdi, S., Alkwai, . S. & Ilyas, . M. (2018) The role of C-terminal tensin-like (Cten) gene in cancer metastasis. JBCGenetics, 1 (1), 2-9. doi:10.24911/JBCGenetics/183-1531548689


Turabian Style

Alghamdi, Saleh, Sarah Alkwai, and Mohammad Ilyas. 2018. The role of C-terminal tensin-like (Cten) gene in cancer metastasis. Journal of Biochemical and Clinical Genetics, 1 (1), 2-9. doi:10.24911/JBCGenetics/183-1531548689


Chicago Style

Alghamdi, Saleh, Sarah Alkwai, and Mohammad Ilyas. "The role of C-terminal tensin-like (Cten) gene in cancer metastasis." Journal of Biochemical and Clinical Genetics 1 (2018), 2-9. doi:10.24911/JBCGenetics/183-1531548689


MLA (The Modern Language Association) Style

Alghamdi, Saleh, Sarah Alkwai, and Mohammad Ilyas. "The role of C-terminal tensin-like (Cten) gene in cancer metastasis." Journal of Biochemical and Clinical Genetics 1.1 (2018), 2-9. Print. doi:10.24911/JBCGenetics/183-1531548689


APA (American Psychological Association) Style

Alghamdi, S., Alkwai, . S. & Ilyas, . M. (2018) The role of C-terminal tensin-like (Cten) gene in cancer metastasis. Journal of Biochemical and Clinical Genetics, 1 (1), 2-9. doi:10.24911/JBCGenetics/183-1531548689


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