Review Article
JBCGenetics. 2018; 1(2): 57-65

Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review

Authors: Khalid Siddiqui, Mohthash Musambil, Adnan Mahmood Usmani.

View PDF HTML Fulltext DOI: 10.24911/JBCGenetics/183-1540811228

Abstract

Type 2 Diabetes (T2D) is a polygenic and multi-factorial complex disease. The significant challenge of finding genetic markers that could be used to predict T2D risk remains unresolved. Saudi Arabia is one of several ethnicities with a high prevalence rate of T2D. A large number of studies have been performed that explored genetic factors associated with T2D risk. In this work, we conducted a systematic review of published studies on T2D genetic markers in the Saudi population. Multiple databases were employed in the literature review, which focused on studies that either reported the association or non-association of a genetic marker with T2D risk. Using appropriate search terms, we collected, analyzed, and selected 428 articles published between the years of 2000-2018, Of these, 18 articles reported a total of 67 polymorphisms in 46 genes that are strongly linked to T2D in the Saudi population. Most of the relevant studies used genotyping as the primary methodology to identify genetic markers of T2D. Most of these studies were published between the years of 2012-2017. A total of 23 polymorphisms in 17 genes were found to be associated with T2D risk in the Saudi population: KCNJ11, PPARG2, IRS1, VDE, WFS1, JAZF1, CDKN2A/B, TCF7L2, KCNQ1, HNF4A, DUSP9, APOE, HNF1A, SLC30A8, APOC3, SNAP25, and ACE.

Keywords:   Type 2 diabetes, Genetics, Saudi Arabia


© Copyright: Author(s)

Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review


Authors
Khalid Siddiqui
Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi Arabia
PubMed articlesGoogle scholar articles

Mohthash Musambil
Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi Arabia
PubMed articlesGoogle scholar articles

Adnan Mahmood Usmani
Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi Arabia
PubMed articlesGoogle scholar articles


Correspondence to:
. Khalid Siddiqui, Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi Arabia; ksiddiqui@ksu.edu.sa

Publication history
Received 29 Oct 2018
Revised 02 Dec 2018
Accepted 08 Jan 2019
Published in print 09 Mar 2019

How to cite this article

Pubmed Style

Siddiqui K, Musambil M, Usmani AM. Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. JBCGenetics. 2018; 1(2): 57-65. doi:10.24911/JBCGenetics/183-1540811228


Web Style

Siddiqui K, Musambil M, Usmani AM. Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. https://www.jbcgenetics.com//?mno=14794 [Access: December 08, 2021]. doi:10.24911/JBCGenetics/183-1540811228


AMA (American Medical Association) Style

Siddiqui K, Musambil M, Usmani AM. Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. JBCGenetics. 2018; 1(2): 57-65. doi:10.24911/JBCGenetics/183-1540811228


Vancouver/ICMJE Style

Siddiqui K, Musambil M, Usmani AM. Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. JBCGenetics. (2018), [cited December 08, 2021]; 1(2): 57-65. doi:10.24911/JBCGenetics/183-1540811228


Harvard Style

Siddiqui, K., Musambil, . M. & Usmani, . A. M. (2018) Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. JBCGenetics, 1 (2), 57-65. doi:10.24911/JBCGenetics/183-1540811228


Turabian Style

Siddiqui, Khalid, Mohthash Musambil, and Adnan Mahmood Usmani. 2018. Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. Journal of Biochemical and Clinical Genetics, 1 (2), 57-65. doi:10.24911/JBCGenetics/183-1540811228


Chicago Style

Siddiqui, Khalid, Mohthash Musambil, and Adnan Mahmood Usmani. "Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review." Journal of Biochemical and Clinical Genetics 1 (2018), 57-65. doi:10.24911/JBCGenetics/183-1540811228


MLA (The Modern Language Association) Style

Siddiqui, Khalid, Mohthash Musambil, and Adnan Mahmood Usmani. "Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review." Journal of Biochemical and Clinical Genetics 1.2 (2018), 57-65. Print. doi:10.24911/JBCGenetics/183-1540811228


APA (American Psychological Association) Style

Siddiqui, K., Musambil, . M. & Usmani, . A. M. (2018) Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. Journal of Biochemical and Clinical Genetics, 1 (2), 57-65. doi:10.24911/JBCGenetics/183-1540811228


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